Mobilization of hematopoietic progenitor cells with paclitaxel (taxol) as a single chemotheraupetic agent, associated with rhG-CSF
نویسندگان
چکیده
منابع مشابه
Mobilization of circulating progenitor cells in multiple myeloma during VCAD therapy with or without rhG-CSF.
BACKGROUND Circulating progenitor cells (CPC), when infused in large numbers, rapidly repopulate the marrow after myeloablation with high-dose therapy. In multiple myeloma (MM), as in other disorders, different chemotherapy regimens, including single-as well as multiple-agent chemotherapy, with or without hemopoietic growth factors, have been proposed to mobilize these progenitor cells into the...
متن کاملeffects of short-term pretreatment with atorvastatin on mobilization of hematopoietic progenitor cells: a double-blind, randomized, controlled trial
background: despite recent advances in mobilization techniques, a considerable portion of patients fail to mobilize sufficient number of cells for successful autologous stem cell transplantation. there are several studies available that have demonstrated enhanced mobilization of endothelial progenitor cells with atorvastatin. therefore, this prospective trial was conducted to evaluate the mobil...
متن کاملEnhanced c-Met activity promotes G-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling.
Mechanisms governing stress-induced hematopoietic progenitor cell mobilization are not fully deciphered. We report that during granulocyte colony-stimulating factor-induced mobilization c-Met expression and signaling are up-regulated on immature bone marrow progenitors. Interestingly, stromal cell-derived factor 1/CXC chemokine receptor-4 signaling induced hepatocyte growth factor production an...
متن کاملInteraction of the anticancer agent Taxol (paclitaxel) with phospholipid bilayers.
Taxol (paclitaxel), a promising agent for use in ovarian and breast cancer, was incorporated into lipid vesicles (liposomes) composed of different saturated and unsaturated phosphatidylcholines, as well as saturated phosphatidylcholines mixed with the anionic phospholipid 1,2-dimyristoyl-sn-glycero-3-phosphatidylserine (DMPS) at different molar ratios, to yield information about Taxol-liposome ...
متن کاملExpression of the G-CSF receptor on hematopoietic progenitor cells is not required for their mobilization by G-CSF.
The mechanisms that regulate hematopoietic progenitor cell (HPC) mobilization from the bone marrow to blood have not yet been defined. HPC mobilization by granulocyte colony-stimulating factor (G-CSF), cyclophosphamide (CY), or interleukin-8 but not flt-3 ligand is markedly impaired in G-CSF receptor-deficient (G-CSFR-deficient) mice. G-CSFR is expressed on mature hematopoietic cells, HPCs, and...
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2000
ISSN: 0268-3369,1476-5365
DOI: 10.1038/sj.bmt.1702130